Cu single atom nanozyme based high-efficiency mild photothermal therapy through cellular metabolic regulation

• Main Authors: Chang, Mengyu, Hou, Zhiyao, Wang, Man, Wen, Ding, Li, Chunxia, Liu, Yuhui, Zhao, Yanli, Lin, Jun
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Heat Shock Proteins; Sodium-Dependent Glucose Transporter
• Online Access: https://hdl.handle.net/10356/170354
• Institution: Nanyang Technological University

Upregulation of heat shock proteins (HSPs) drastically compromises the treatment effect of mild photothermal therapy (PTT). Herein, we designed a polyporous Cu single atom nanozyme (Cu SAzyme) loaded with licogliflozin (LIK066) for HSP-silencing induced mild PTT. On one hand, LIK066 inhibits glucose...