Cu single atom nanozyme based high-efficiency mild photothermal therapy through cellular metabolic regulation

• المؤلفون الرئيسيون: Chang, Mengyu, Hou, Zhiyao, Wang, Man, Wen, Ding, Li, Chunxia, Liu, Yuhui, Zhao, Yanli, Lin, Jun
• مؤلفون آخرون: School of Chemistry, Chemical Engineering and Biotechnology
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Chemistry; Heat Shock Proteins; Sodium-Dependent Glucose Transporter
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/170354
• المؤسسة: Nanyang Technological University

Upregulation of heat shock proteins (HSPs) drastically compromises the treatment effect of mild photothermal therapy (PTT). Herein, we designed a polyporous Cu single atom nanozyme (Cu SAzyme) loaded with licogliflozin (LIK066) for HSP-silencing induced mild PTT. On one hand, LIK066 inhibits glucose...