Modulating neuroinflammation through molecular, cellular and biomaterial-based approaches to treat spinal cord injury

• Main Authors: Lee, Cheryl Yi-Pin, Chooi, Wai Hon, Ng, Shi-Yan, Chew, Sing Yian
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Central Nervous System; Inflammatory Response
• Online Access: https://hdl.handle.net/10356/170431
• Institution: Nanyang Technological University

The neuroinflammatory response that is elicited after spinal cord injury contributes to both tissue damage and reparative processes. The complex and dynamic cellular and molecular changes within the spinal cord microenvironment result in a functional imbalance of immune cells and their modulatory factors. To facilitate wound healing and repair, it is necessary to manipulate the immunological pathways during neuroinflammation to achieve successful therapeutic interventions. In this review, recent advancements and fresh perspectives on the consequences of neuroinflammation after SCI and modulation of the inflammatory responses through the use of molecular-, cellular-, and biomaterial-based therapies to promote tissue regeneration and functional recovery will be discussed.