NHC‐catalyzed chemoselective reactions of enals and aminobenzaldehydes for access to chiral dihydroquinolines

• المؤلفون الرئيسيون: Wu, Shuquan, Liu, Changyi, Luo, Guoyong, Jin, Zhichao, Zheng, Pengcheng, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Chemistry; Chemoselectivity; Dihydroquinolines
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/170458
• المؤسسة: Nanyang Technological University

An N-heterocyclic carbene (NHC)-catalyzed reaction between α-bromoenals and 2-aminoaldehydes has been developed. Key steps include chemoselective reaction of the NHC catalyst with one of the aldehyde substrates (the bromoenal) to eventually generate an α,β-unsaturated acylazolium intermediate. Addit...