Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy
Most patients are at high risk of thrombosis during cancer treatment. However, the major discrepancy in the therapeutic mechanisms and microenvironment between tumors and thrombosis makes it challenging for a panacea to treat cancer while being able to eliminate the risk of thrombosis. Herein, we de...
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sg-ntu-dr.10356-1705112023-09-18T01:12:17Z Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy Zhang, Kai Ma, Zhaoyu Li, Shuting Zhang, Weiyun Foda, Mohamed Frahat Zhao, Yanli Han, Heyou School of Chemistry, Chemical Engineering and Biotechnology Engineering::Bioengineering Hirudin Platelet Membrane Most patients are at high risk of thrombosis during cancer treatment. However, the major discrepancy in the therapeutic mechanisms and microenvironment between tumors and thrombosis makes it challenging for a panacea to treat cancer while being able to eliminate the risk of thrombosis. Herein, we developed a biomimetic MnOx/Ag2S nanoflower platform with platelet membrane modification (MnOx@Ag2S@hirudin@platelet membrane: MAHP) for the long-term release of anticoagulant drugs to treat thrombosis together with tumor therapy. This MAHP platform could achieve the targeted delivery of hirudin to the thrombus site and perform the controlled release under the irradiation of near-infrared light, demonstrating effective removal of the thrombus. Moreover, MAHP could inhibit tumor progression and prolong the survival time of mice with thromboembolic complications. This work was supported by the National Key R & D Program of China (2021YFD1400800). 2023-09-18T01:12:17Z 2023-09-18T01:12:17Z 2022 Journal Article Zhang, K., Ma, Z., Li, S., Zhang, W., Foda, M. F., Zhao, Y. & Han, H. (2022). Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy. ACS Nano, 16(11), 18483-18496. https://dx.doi.org/10.1021/acsnano.2c06666 1936-0851 https://hdl.handle.net/10356/170511 10.1021/acsnano.2c06666 36350264 2-s2.0-85141961427 11 16 18483 18496 en ACS Nano © 2022 American Chemical Society. All rights reserved. |
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Engineering::Bioengineering Hirudin Platelet Membrane Zhang, Kai Ma, Zhaoyu Li, Shuting Zhang, Weiyun Foda, Mohamed Frahat Zhao, Yanli Han, Heyou Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy |
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Most patients are at high risk of thrombosis during cancer treatment. However, the major discrepancy in the therapeutic mechanisms and microenvironment between tumors and thrombosis makes it challenging for a panacea to treat cancer while being able to eliminate the risk of thrombosis. Herein, we developed a biomimetic MnOx/Ag2S nanoflower platform with platelet membrane modification (MnOx@Ag2S@hirudin@platelet membrane: MAHP) for the long-term release of anticoagulant drugs to treat thrombosis together with tumor therapy. This MAHP platform could achieve the targeted delivery of hirudin to the thrombus site and perform the controlled release under the irradiation of near-infrared light, demonstrating effective removal of the thrombus. Moreover, MAHP could inhibit tumor progression and prolong the survival time of mice with thromboembolic complications. |
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School of Chemistry, Chemical Engineering and Biotechnology |
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School of Chemistry, Chemical Engineering and Biotechnology Zhang, Kai Ma, Zhaoyu Li, Shuting Zhang, Weiyun Foda, Mohamed Frahat Zhao, Yanli Han, Heyou |
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Article |
author |
Zhang, Kai Ma, Zhaoyu Li, Shuting Zhang, Weiyun Foda, Mohamed Frahat Zhao, Yanli Han, Heyou |
author_sort |
Zhang, Kai |
title |
Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy |
title_short |
Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy |
title_full |
Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy |
title_fullStr |
Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy |
title_full_unstemmed |
Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy |
title_sort |
platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy |
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2023 |
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https://hdl.handle.net/10356/170511 |
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1779156303325691904 |