Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy

• Main Authors: Zhang, Kai, Ma, Zhaoyu, Li, Shuting, Zhang, Weiyun, Foda, Mohamed Frahat, Zhao, Yanli, Han, Heyou
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Hirudin; Platelet Membrane
• Online Access: https://hdl.handle.net/10356/170511
• Institution: Nanyang Technological University

Most patients are at high risk of thrombosis during cancer treatment. However, the major discrepancy in the therapeutic mechanisms and microenvironment between tumors and thrombosis makes it challenging for a panacea to treat cancer while being able to eliminate the risk of thrombosis. Herein, we de...