The mood stabilizer lithium slows down synaptic vesicle cycling at glutamatergic synapses

• Main Authors: Tang, Willcyn, Cory, Bradley, Lim, Kah-Leong, Fivaz, Marc
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Bipolar Disorder; Synaptic Vesicle Cycle
• Online Access: https://hdl.handle.net/10356/170540
• Institution: Nanyang Technological University

Lithium is a mood stabilizer broadly used to prevent and treat symptoms of mania and depression in people with bipolar disorder (BD). Little is known, however, about its mode of action. Here, we analyzed the impact of lithium on synaptic vesicle (SV) cycling at presynaptic terminals releasing glutam...