The mood stabilizer lithium slows down synaptic vesicle cycling at glutamatergic synapses

• المؤلفون الرئيسيون: Tang, Willcyn, Cory, Bradley, Lim, Kah-Leong, Fivaz, Marc
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Medicine; Bipolar Disorder; Synaptic Vesicle Cycle
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/170540
• المؤسسة: Nanyang Technological University

Lithium is a mood stabilizer broadly used to prevent and treat symptoms of mania and depression in people with bipolar disorder (BD). Little is known, however, about its mode of action. Here, we analyzed the impact of lithium on synaptic vesicle (SV) cycling at presynaptic terminals releasing glutam...