Plant‑derived cell‑penetrating microprotein α‑astratide aM1 targets Akt signaling and alleviates insulin resistance

• Main Authors: Dutta, Bamaprasad, Loo, Shining, Kam, Antony, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Leginsulin; Diabetes; α-Astratide; Cell Penetration; Microproteins; Glucose Uptake; Insulin Resistance; Insulin-Mimetic; PI3K/Akt Signaling; IRS1/2; PKCθ; Cholesterol Biosynthesis
• Online Access: https://hdl.handle.net/10356/170608
• Institution: Nanyang Technological University

Insulin-resistant diabetes is a common metabolic disease with serious complications. Treatments directly addressing the underlying molecular mechanisms involving insulin resistance would be desirable. Our laboratory recently identified a proteolytic-resistant cystine-dense microprotein from huáng qí...