Inhibiting respiration as a novel antibiotic strategy

• Main Authors: Lee, Bei Shi, Singh, Samsher, Pethe, Kevin
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Adenosine Triphosphate; Antibiotic Agent
• Online Access: https://hdl.handle.net/10356/170915
• Institution: Nanyang Technological University

The approval of the first-in-class antibacterial bedaquiline for tuberculosis marks a breakthrough in antituberculosis drug development. The drug inhibits mycobacterial respiration and represents the validation of a wholly different metabolic process as a druggable target space. In this review, we d...