Bortezomib-encapsulated dual responsive copolymeric nanoparticles for gallbladder cancer targeted therapy

• Main Authors: Chen, Mingyu, Juengpanich, Sarun, Li, Shijie, Topatana, Win, Lu, Ziyi, Zheng, Qiang, Cao, Jiasheng, Hu, Jiahao, Chan, Esther, Hou, Lidan, Chen, Jiang, Chen, Fang, Liu, Yu, Jiansirisomboon, Sukanda, Gu, Zhen, Tongpeng, Suparat, Cai, Xiujun
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Antineoplastic Agents; Tumor Microenvironment
• Online Access: https://hdl.handle.net/10356/170940
• Institution: Nanyang Technological University

Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As a proteasome inhibitor, bortezomib (BTZ) exhibits excellent antitumor ability in GBC. However, the long-term treatmen...