Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis

Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis

Massive expansion of immature and suppressive myeloid cells is a common feature of malignant solid tumors. Over-expression of cyclin-dependent kinase 20, also known as cell cycle-related kinase (CCRK), in hepatocellular carcinoma (HCC) correlates with reduced patient survival and low immunotherapy r...

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Bibliographic Details
Main Authors: Zhou, Jingying, Wang, Huanyu, Shu, Ting, Wang, Jing, Yang, Weiqin, Li, Jingqing, Ding, Lipeng, Liu, Man, Sun, Hanyong, Wong, John, Lai, Paul Bo-San, Tsang, Shun-Wa, Ward, Simon E., Chow, King-Lau, Sung, Joseph Jao Yiu, Cheng, Alfred Sze-Lok
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Microenvironment
Molecular Biology
Online Access:https://hdl.handle.net/10356/171559
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/171559

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