Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis

• Main Authors: Zhou, Jingying, Wang, Huanyu, Shu, Ting, Wang, Jing, Yang, Weiqin, Li, Jingqing, Ding, Lipeng, Liu, Man, Sun, Hanyong, Wong, John, Lai, Paul Bo-San, Tsang, Shun-Wa, Ward, Simon E., Chow, King-Lau, Sung, Joseph Jao Yiu, Cheng, Alfred Sze-Lok
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Microenvironment; Molecular Biology
• Online Access: https://hdl.handle.net/10356/171559
• Institution: Nanyang Technological University

Massive expansion of immature and suppressive myeloid cells is a common feature of malignant solid tumors. Over-expression of cyclin-dependent kinase 20, also known as cell cycle-related kinase (CCRK), in hepatocellular carcinoma (HCC) correlates with reduced patient survival and low immunotherapy r...