Structural and dynamical investigation of histone H2B in well-hydrated nucleosome core particles by solid-state NMR

• Main Authors: Shi, Xiangyan, Kannaian, Bhuvaneswari, Prasanna, Chinmayi, Soman, Aghil, Nordenskiöld, Lars
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Histone; Nucleosome
• Online Access: https://hdl.handle.net/10356/170947
• Institution: Nanyang Technological University

H2A-H2B dimer is a key component of nucleosomes and an important player in chromatin biology. Here, we characterized the structure and dynamics of H2B in precipitated nucleosome core particles (NCPs) with a physiologically relevant concentration using solid-state NMR. Our recent investigation of H3-...