Monitoring disassembly and cargo release of phase-separated peptide coacervates with native mass spectrometry

Monitoring disassembly and cargo release of phase-separated peptide coacervates with native mass spectrometry

Engineering liquid-liquid phase separation (LLPS) of proteins and peptides holds great promise for the development of therapeutic carriers with intracellular delivery capability but requires accurate determination of their assembly properties in vitro, usually with fluorescently labeled cargo. Here,...

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Bibliographic Details
Main Authors: Cerrato, Carmine P., Leppert, Axel, Sun, Yue, Lane, David P., Arsenian-Henriksson, Marie, Miserez, Ali, Landreh, Michael
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2023
Subjects:
Engineering::Materials
Native Mass Spectrometry
Peptide Coacervates
Online Access:https://hdl.handle.net/10356/171059
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/171059

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