A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging

• Main Authors: Kovács, Tibor, Szinyákovics, Janka, Billes, Viktor, Murányi, Gábor, Varga, Virginia B., Bjelik, Annamária, Légrádi, Ádám, Szabó, Melinda, Sándor, Sára, Kubinyi, Enikő, Szekeres-Paracky, Cecília, Szocsics, Péter, Lőke, János, Mulder, Jun, Gulyás, Balázs, Renner, Éva, Palkovits, Miklós, Gulya, Károly, Maglóczky, Zsófia, Vellai, Tibor
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Drosophila Protein; Drosophila Melanogaster
• Online Access: https://hdl.handle.net/10356/171290
• Institution: Nanyang Technological University

Ageing is driven by the progressive, lifelong accumulation of cellular damage. Autophagy (cellular self-eating) functions as a major cell clearance mechanism to degrade such damages, and its capacity declines with age. Despite its physiological and medical significance, it remains largely unknown wh...