JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1

JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1

The c-Jun-NH2-terminal kinases (JNKs) regulate cell death, generally through the direct phosphorylation of both pro- and anti-apoptotic substrates. In this report, we demonstrate an alternate mechanism of JNK-mediated cell death involving the anti-apoptotic protein human apurinic/apyrimidinic endonu...

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Bibliographic Details
Main Authors: Tabanifar, Bahareh, Moorthy, Anbalagan, Tsai, Heng Hang, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Sabapathy, Kanaga
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2023
Subjects:
Science::Biological sciences
Apoptosis
APE1
Online Access:https://hdl.handle.net/10356/171372
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/171372

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