JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1

• Main Authors: Tabanifar, Bahareh, Moorthy, Anbalagan, Tsai, Heng Hang, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Sabapathy, Kanaga
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Apoptosis; APE1
• Online Access: https://hdl.handle.net/10356/171372
• Institution: Nanyang Technological University

The c-Jun-NH2-terminal kinases (JNKs) regulate cell death, generally through the direct phosphorylation of both pro- and anti-apoptotic substrates. In this report, we demonstrate an alternate mechanism of JNK-mediated cell death involving the anti-apoptotic protein human apurinic/apyrimidinic endonu...