Recent developments in chemical conjugation strategies targeting native amino acids in proteins and their applications in antibody-drug conjugates

• المؤلفون الرئيسيون: Kang, Min Sun, Kong, Theresa Wai See, Khoo, Joycelyn Yi Xin, Loh, Teck-Peng
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Chemistry; Amino-Acids; Antibody-Drug Conjugates
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/171448
• المؤسسة: Nanyang Technological University

Many fields in chemical biology and synthetic biology require effective bioconjugation methods to achieve their desired functions and activities. Among such biomolecule conjugates, antibody-drug conjugates (ADCs) need a linker that provides a stable linkage between cytotoxic drugs and antibodies, whilst conjugating in a biologically benign, fast and selective fashion. This review focuses on how the development of novel organic synthesis can solve the problems of traditional linker technology. The review shall introduce and analyse the current developments in the modification of native amino acids on peptides or proteins and their applicability to ADC linker. Thereafter, the review shall discuss in detail each endogenous amino acid's intrinsic reactivity and selectivity aspects, and address the research effort to construct an ADC using each conjugation method.