Recent developments in chemical conjugation strategies targeting native amino acids in proteins and their applications in antibody-drug conjugates

• Main Authors: Kang, Min Sun, Kong, Theresa Wai See, Khoo, Joycelyn Yi Xin, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Amino-Acids; Antibody-Drug Conjugates
• Online Access: https://hdl.handle.net/10356/171448
• Institution: Nanyang Technological University

Many fields in chemical biology and synthetic biology require effective bioconjugation methods to achieve their desired functions and activities. Among such biomolecule conjugates, antibody-drug conjugates (ADCs) need a linker that provides a stable linkage between cytotoxic drugs and antibodies, wh...