Localized transverse flow measurement with dynamic light scattering line-scan OCT

Localized transverse flow measurement with dynamic light scattering line-scan OCT

A novel decorrelation-based approach for measuring localized transverse flow velocity using line-scan (LS) optical coherence tomography (OCT) is proposed. The new approach allows for separation of the flow velocity component along the line-illumination direction of the imaging beam from other orthog...

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Bibliographic Details
Main Authors: Han, Le, Tan, Bingyao, Schmetterer, Leopold, Bizheva, Kostadinka
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Optical Coherence Tomography
Transverse Velocity
Online Access:https://hdl.handle.net/10356/171479
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Institution: Nanyang Technological University
Language: English
Description
Summary:A novel decorrelation-based approach for measuring localized transverse flow velocity using line-scan (LS) optical coherence tomography (OCT) is proposed. The new approach allows for separation of the flow velocity component along the line-illumination direction of the imaging beam from other orthogonal velocity components, from particle diffusion motion, and from noise-induced distortion in the OCT signal's temporal autocorrelation. The new method was verified by imaging flow in a glass capillary and a microfluidic device and mapping the spatial distribution of the flow velocity within the beam's illumination plane. This method can be extended in the future to map the three-dimensional flow velocity fields for both ex-vivo and in-vivo applications.

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