Localized transverse flow measurement with dynamic light scattering line-scan OCT

• Main Authors: Han, Le, Tan, Bingyao, Schmetterer, Leopold, Bizheva, Kostadinka
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Optical Coherence Tomography; Transverse Velocity
• Online Access: https://hdl.handle.net/10356/171479
• Institution: Nanyang Technological University

A novel decorrelation-based approach for measuring localized transverse flow velocity using line-scan (LS) optical coherence tomography (OCT) is proposed. The new approach allows for separation of the flow velocity component along the line-illumination direction of the imaging beam from other orthogonal velocity components, from particle diffusion motion, and from noise-induced distortion in the OCT signal's temporal autocorrelation. The new method was verified by imaging flow in a glass capillary and a microfluidic device and mapping the spatial distribution of the flow velocity within the beam's illumination plane. This method can be extended in the future to map the three-dimensional flow velocity fields for both ex-vivo and in-vivo applications.