Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice

• Main Authors: Firth, George, Georgiadou, Eleni, Griffiths, Alexander, Amrahli, Maral, Kim, Jana, Yu, Zilin, Hu, Ming, Stewart, Theodora J., Leclerc, Isabelle, Okamoto, Haruka, Gomez, Daniel, Blower, Philip J., Rutter, Guy A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Isoflurane; Manganese
• Online Access: https://hdl.handle.net/10356/171507
• Institution: Nanyang Technological University

Common variants in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8 (expressed largely in pancreatic islet alpha and beta cells), are associated with altered risk of type 2 diabetes. Unexpectedly, rare loss-of-function (LoF) variants in the gene, described in heterozygous indiv...