A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

• Main Authors: Pabis, Kamil, Barardo, Diogo, Selvarajoo, Kumar, Gruber, Jan, Kennedy, Brian K.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Aging; Algorithm
• Online Access: https://hdl.handle.net/10356/171514
• Institution: Nanyang Technological University

Aging and senescence are characterized by pervasive transcriptional dysfunction, including increased expression of transposons and introns. Our aim was to elucidate mechanisms behind this increased expression. Most transposons are found within genes and introns, with a large minority being close to...