A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence
Aging and senescence are characterized by pervasive transcriptional dysfunction, including increased expression of transposons and introns. Our aim was to elucidate mechanisms behind this increased expression. Most transposons are found within genes and introns, with a large minority being close to...
Saved in:
Main Authors: | Pabis, Kamil, Barardo, Diogo, Selvarajoo, Kumar, Gruber, Jan, Kennedy, Brian K. |
---|---|
Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2023
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/171514 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Similar Items
-
Increased intron retention is a post-transcriptional signature associated with progressive aging and Alzheimer’s disease
by: Adusumalli, S., et al.
Published: (2022) -
EXTENDING HEALTHY LIFESPAN BY SYSTEMATICALLY TARGETING AGEING PATHWAYS SYNERGIES
by: DIOGO GONCALVES BARARDO
Published: (2021) -
Increased intron retention is linked to Alzheimer's disease
by: Ong, C.-T., et al.
Published: (2021) -
Markers of T Cell Senescence in Humans
by: Xu, Weili, et al.
Published: (2017) -
Antisense Oligonucleotide-Mediated Terminal Intron Retention of the SMN2 Transcript
by: Loren L. Flynn, et al.
Published: (2019)