Multifunctional cytomegalovirus (CMV)-specific CD8+ T cells are not restricted by telomere-related senescence in young or old adults

• Main Authors: Riddell, N.E, Griffiths, S.J, Rivino, L, King, D.C.B, Teo, G.H, Henson, S.M, Cantisan, S, Solana, R, Kemeny, D.M, Macary, P.A, Larbi, A, Akbar, A.N
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Blackwell Publishing Ltd 2020
• Subjects: CD27 antigen; CD45RA antigen; gamma interferon; interleukin 2; quantum dot; tumor necrosis factor alpha; biological marker; CD45 antigen; cytokine; adult; aged; antigen specificity; Article; Asian; Caucasian; CD8+ T lymphocyte; cell aging; cohort analysis; cytokine production; cytokine release; Cytomegalovirus; cytomegalovirus infection; flow cytometry; fluorescence in situ hybridization; groups by age; human; human cell; lymphocyte differentiation; nonhuman; normal human; peripheral blood mononuclear cell; priority journal; protein expression; senescence; T lymphocyte subpopulation; telomere homeostasis; thermostability; age; aging; Asian continental ancestry group; cell culture; cell differentiation; cell proliferation; clinical trial; comparative study; England; ethnology; genetics; immunology; immunophenotyping; lymphocyte activation; metabolism; multicenter study; pathogenicity; phenotype; procedures; Singapore; telomere; telomere shortening; very elderly; virology; young adult; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Antigens, CD27; Antigens, CD45; Asian Continental Ancestry Group; Biomarkers; CD8-Positive T-Lymphocytes; Cell Aging; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cytokines; Cytomegalovirus Infections; European Continental Ancestry Group; Flow Cytometry; Humans; Immunophenotyping; London; Lymphocyte Activation; Phenotype; Telomere; Telomere Shortening; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175295
• Institution: National University of Singapore

10.1111/imm.12409