Thiol-specific silicon-containing conjugating reagent: β-silyl alkynyl carbonyl compounds

• Main Authors: Teng, Shenghan, Zhang, Zhenguo, Li, Bohan, Li, Lanyang, Tan, Melinda Chor Li, Jia, Zhenhua, Loh, Teck-Peng
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Alkynyl Carbonyl Reagents; Biocompatibility
• Online Access: https://hdl.handle.net/10356/171658
• Institution: Nanyang Technological University

Site-specific modification of thiol-containing biomolecules has been recognized as a versatile and powerful strategy for probing our biological systems and discovering novel therapeutics. The addition of lipophilic silicon moiety opens up new avenues for multi-disciplinary research with broad applic...