Clopidogrel administration impairs post-stroke learning and memory recovery in mice

• Main Authors: Paul, Marina, Paul, Jonathan W., Hinwood, Madeleine, Hood, Rebecca J., Martin, Kristy, Abdolhoseini, Mahmoud, Johnson, Sarah J., Pollack, Michael, Nilsson, Michael, Walker, Frederick R.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Stroke; Microglia
• Online Access: https://hdl.handle.net/10356/171757
• Institution: Nanyang Technological University

Clopidogrel, which is one of the most prescribed antiplatelet medications in the world, is given to stroke survivors for the prevention of secondary cardiovascular events. Clopidogrel exerts its antiplatelet activity via antagonism of the P2Y12 receptor (P2RY12). Although not widely known or conside...