Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response

• المؤلفون الرئيسيون: Tan, Ivan, Xu, Shengli, Huo, Jianxin, Huang, Yuhan, Lim, Hong-Hwa, Lam, Kong-Peng
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Biological sciences; Cellular Localization; DNA Damage
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/171766
• المؤسسة: Nanyang Technological University

The tumor suppressor Liver Kinase B1 (LKB1) is a multifunctional serine/threonine protein kinase that regulates cell metabolism, polarity, and growth and is associated with Peutz-Jeghers Syndrome and cancer predisposition. The LKB1 gene comprises 10 exons and 9 introns. Three spliced LKB1 variants h...