The cytoplasmic domain of the SARS-CoV-2 envelope protein assembles into a β-sheet bundle in lipid bilayers

• المؤلفون الرئيسيون: Dregni, Aurelio J., McKay, Matthew J., Surya, Wahyu, Queralt-Martin, Maria, Medeiros-Silva, João, Wang, Harrison K., Aguilella, Vicente, Torres, Jaume, Hong, Mei
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Biological sciences; Membrane Curvature; Oligomerization
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/171791
• المؤسسة: Nanyang Technological University

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein forms a pentameric ion channel in the lipid membrane of the endoplasmic reticulum Golgi intermediate compartment (ERGIC) of the infected cell. The cytoplasmic domain of E interacts with host proteins to cause virus...