Phase separation in biology and disease; current perspectives and open questions

• Main Authors: Boeynaems, Steven, Chong, Shasha, Gsponer, Jörg, Holt, Liam, Milovanovic, Dragomir, Mitrea, Diana M., Mueller-Cajar, Oliver, Portz, Bede, Reilly, John F., Reinkemeier, Christopher D., Sabari, Benjamin R., Sanulli, Serena, Shorter, James, Sontag, Emily, Strader, Lucia, Stachowiak, Jeanne, Weber, Stephanie C., White, Michael, Zhang, Huaiying, Zweckstetter, Markus, Elbaum-Garfinkle, Shana, Kriwacki, Richard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Biomolecular Condensates; Membraneless Organelles
• Online Access: https://hdl.handle.net/10356/171794
• Institution: Nanyang Technological University

In the past almost 15 years, we witnessed the birth of a new scientific field focused on the existence, formation, biological functions, and disease associations of membraneless bodies in cells, now referred to as biomolecular condensates. Pioneering studies from several laboratories [reviewed in1-3...