Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease

• Main Authors: Qiang, Yuhao, Sissoko, Abdoulaye, Liu, Zixiang L., Dong, Ting, Zheng, Fuyin, Kong, Fang, Higgins, John M., Karniadakis, George E., Buffet, Pierre A., Suresh, Subra, Dao, Ming
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Hypoxia; Acute Splenic Sequestration Crisis
• Online Access: https://hdl.handle.net/10356/172028
• Institution: Nanyang Technological University

The spleen clears altered red blood cells (RBCs) from circulation, contributing to the balance between RBC formation (erythropoiesis) and removal. The splenic RBC retention and elimination occur predominantly in open circulation where RBCs flow through macrophages and inter-endothelial slits (IESs)....