vPIF-1 is an insulin-like antiferroptotic viral peptide

• Main Authors: Belavgeni, Alexia, Maremonti, Francesca, Tonnus, Wulf, Stadtmüller, Marlena, Gavali, Shubhangi, Mallais, Melodie, Flade, Karolin, Brucker, Anne, Becker, Jorunn Naila, Beer, Kristina, Tmava, Mirela, Stumpf, Julian, Gembardt, Florian, Hugo, Christian, Giacca, Mauro, Hale, Benjamin G., Perakakis, Nikolaos, Sha, Wei, Pratt, Derek A., Schally, Andrew V., Bornstein, Stefan R., Linkermann, Andreas
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Regulated Necrosis; Ferroptosis
• Online Access: https://hdl.handle.net/10356/172030
• Institution: Nanyang Technological University

Iridoviridae, such as the lymphocystis disease virus-1 (LCDV-1) and other viruses, encode viral insulin-like peptides (VILPs) which are capable of triggering insulin receptors (IRs) and insulin-like growth factor receptors. The homology of VILPs includes highly conserved disulfide bridges. However,...