Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loa...

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Bibliographic Details
Main Authors: Onbasli, Kubra, Demirci, Gozde, Isik, Furkan, Durmusoglu, Emek Goksu, Demir, Hilmi Volkan, Acar, Havva Yagci
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2023
Subjects:
Science::Chemistry
Nanoplatelet
Cancer Cells
Online Access:https://hdl.handle.net/10356/172114
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Institution: Nanyang Technological University
Language: English
Description
Summary:Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.

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