Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia

• Main Authors: Vipin, Ashwati, Koh, Chen Ling, Wong, Benjamin Yi Xin, Zailan, Fatin Zahra, Tan, Jayne Yi, Soo, See Ann, Satish, Vaynii, Kumar, Dilip, Wang, Brian Zhiyang, Ng, Adeline Su Lyn, Chiew, Hui Jin, Ng, Kok Pin, Kandiah, Nagaendran
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Cognition; Longitudinal
• Online Access: https://hdl.handle.net/10356/172174
• Institution: Nanyang Technological University

We examined amyloid-tau-neurodegeneration biomarker effects on cognition in a Southeast-Asian cohort of 84 sporadic young-onset dementia (YOD; age-at-onset <65 years) patients. They were stratified into A+N+, A- N+, and A- N- profiles via cerebrospinal fluid amyloid-β1-42 (A), phosphorylated-tau...