Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au

Wound infection impedes wound healing and thus poses serious health risks in humans. Wound healing conventionally relies on gauze, lint, plasters, bandages, and cotton wool, with heavy doses of antibiotics in some of them. While silver-based materials have emerged as potential alternatives to antibi...

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Main Authors: Sen, Raj Kumar., Prabhakar, Priyanka, Mayandi, Venkatesh, Dwivedi, Neeraj, Yadav, Amit K., Solanki, Pratima R., Gupta, Ayush, Gowri, V. S., Lakshminarayanan, Rajamani, Verma, Navin Kumar, Mondal, D. P., Srivastava, Avanish Kumar, Dhand, Chetna
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/172278
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spelling sg-ntu-dr.10356-1722782023-12-05T01:37:55Z Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au Sen, Raj Kumar. Prabhakar, Priyanka Mayandi, Venkatesh Dwivedi, Neeraj Yadav, Amit K. Solanki, Pratima R. Gupta, Ayush Gowri, V. S. Lakshminarayanan, Rajamani Verma, Navin Kumar Mondal, D. P. Srivastava, Avanish Kumar Dhand, Chetna Lee Kong Chian School of Medicine (LKCMedicine) Singapore Eye Research Institute National Skin Centre, Singapore Science::Medicine Hydrogel Antimicrobial Wound infection impedes wound healing and thus poses serious health risks in humans. Wound healing conventionally relies on gauze, lint, plasters, bandages, and cotton wool, with heavy doses of antibiotics in some of them. While silver-based materials have emerged as potential alternatives to antibiotics in wound care management, they are expensive (gold is an even more expensive antimicrobial agent), and their excessive use may promote silver-resistant microbial strains, and skin argyrosis. Furthermore, excessive wound exudate causes conventional wound dressings to become moistened and painful to remove due to adhesion to the wound. We present non-traditional yet high-performance hydrogel (HG)-based wound films based on polyvinyl alcohol (PVA), chitosan (CS), polyethylene glycol (PEG), and effective antibacterial metal ions (Zn2+, Cu2+, Ag+, Au3+, and Mg2+) for wound infection management. The resulting HG_Cu, HG_Zn, HG_Ag, and HG_Au films demonstrated excellent antibacterial efficacy against S. aureus, A. baumanni, and C. albicans, as well as high water absorption (213%, 169.50%, 338.62%, and 241.22%, respectively), swellability (3.21, 2.69, 4.38, and 3.41, respectively), and outstanding thermal stability. Strikingly, the Cu and Zn integrated hydrogels demonstrated broad-spectrum antimicrobial properties. The findings of this work thus reveal a more cost-effective, sustainable, and environmentally friendly approach to designing high-value-added wound care products. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) RKS is thankful to the Council of Scientific and Industrial Research (CSIR), India, for the award of the Junior Research Fellowship (31/041 (082)/2019-EMR-I). AKY is grateful to the Ministry of Education, Govt. of India, for the award of the Prime Minister Research Fellowship (PMRF). CD acknowledges the funding support received from Science and Engineering Research Board (SERB), India (SRG/2020/001215). The authors thank CSIR, India for financial support through focussed basic research (FBR) projects (MLP-204 and MLP205). NKV acknowledges funding support from the Agency for Science, Technology, and Research (A*STAR) under its Wound Care Innovation for the Tropics (WCIT) Industry Alignment Fund Pre-Positioning (IAF-PP) grant (H17/ 01/a0/0K9), the Strategic Academic Initiative (SAI) Grant (L0494003), and the Singapore Ministry of Education (MOE) Academic Research Fund (AcRF) Tier 1 (2020-T1-001-062) grants. 2023-12-05T01:37:55Z 2023-12-05T01:37:55Z 2023 Journal Article Sen, R. K., Prabhakar, P., Mayandi, V., Dwivedi, N., Yadav, A. K., Solanki, P. R., Gupta, A., Gowri, V. S., Lakshminarayanan, R., Verma, N. K., Mondal, D. P., Srivastava, A. K. & Dhand, C. (2023). Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au. Materials Chemistry and Physics, 297, 127365-. https://dx.doi.org/10.1016/j.matchemphys.2023.127365 0254-0584 https://hdl.handle.net/10356/172278 10.1016/j.matchemphys.2023.127365 2-s2.0-85149743602 297 127365 en H17/01/a0/0K9 L0494003 2020-T1-001-062 Materials Chemistry and Physics © 2023 Elsevier B.V. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Hydrogel
Antimicrobial
spellingShingle Science::Medicine
Hydrogel
Antimicrobial
Sen, Raj Kumar.
Prabhakar, Priyanka
Mayandi, Venkatesh
Dwivedi, Neeraj
Yadav, Amit K.
Solanki, Pratima R.
Gupta, Ayush
Gowri, V. S.
Lakshminarayanan, Rajamani
Verma, Navin Kumar
Mondal, D. P.
Srivastava, Avanish Kumar
Dhand, Chetna
Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au
description Wound infection impedes wound healing and thus poses serious health risks in humans. Wound healing conventionally relies on gauze, lint, plasters, bandages, and cotton wool, with heavy doses of antibiotics in some of them. While silver-based materials have emerged as potential alternatives to antibiotics in wound care management, they are expensive (gold is an even more expensive antimicrobial agent), and their excessive use may promote silver-resistant microbial strains, and skin argyrosis. Furthermore, excessive wound exudate causes conventional wound dressings to become moistened and painful to remove due to adhesion to the wound. We present non-traditional yet high-performance hydrogel (HG)-based wound films based on polyvinyl alcohol (PVA), chitosan (CS), polyethylene glycol (PEG), and effective antibacterial metal ions (Zn2+, Cu2+, Ag+, Au3+, and Mg2+) for wound infection management. The resulting HG_Cu, HG_Zn, HG_Ag, and HG_Au films demonstrated excellent antibacterial efficacy against S. aureus, A. baumanni, and C. albicans, as well as high water absorption (213%, 169.50%, 338.62%, and 241.22%, respectively), swellability (3.21, 2.69, 4.38, and 3.41, respectively), and outstanding thermal stability. Strikingly, the Cu and Zn integrated hydrogels demonstrated broad-spectrum antimicrobial properties. The findings of this work thus reveal a more cost-effective, sustainable, and environmentally friendly approach to designing high-value-added wound care products.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Sen, Raj Kumar.
Prabhakar, Priyanka
Mayandi, Venkatesh
Dwivedi, Neeraj
Yadav, Amit K.
Solanki, Pratima R.
Gupta, Ayush
Gowri, V. S.
Lakshminarayanan, Rajamani
Verma, Navin Kumar
Mondal, D. P.
Srivastava, Avanish Kumar
Dhand, Chetna
format Article
author Sen, Raj Kumar.
Prabhakar, Priyanka
Mayandi, Venkatesh
Dwivedi, Neeraj
Yadav, Amit K.
Solanki, Pratima R.
Gupta, Ayush
Gowri, V. S.
Lakshminarayanan, Rajamani
Verma, Navin Kumar
Mondal, D. P.
Srivastava, Avanish Kumar
Dhand, Chetna
author_sort Sen, Raj Kumar.
title Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au
title_short Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au
title_full Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au
title_fullStr Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au
title_full_unstemmed Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au
title_sort metal mediated high performance antimicrobial hydrogel films for wound infection management: zn, cu, and mg versus ag and au
publishDate 2023
url https://hdl.handle.net/10356/172278
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