Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study

The development of bone grafts and prosthetic implants for clinical need is still difficult due to the complexity of integrated physiological processes. The 58S glass ceramic is one of the most widely accepted biomaterial for preparing hard tissue damages due to its capability to react at molecular...

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Main Authors:	Chandran, Likha, Marimuthu, Arumugam, Abimanyu, Ravichandran, Padmanabhan, Parasuraman, Thirumavalavan, Munusamy, Ballamurugan, Anbalagan M.
Other Authors:	Lee Kong Chian School of Medicine (LKCMedicine)
Format:	Article
Language:	English
Published:	2023
Subjects:	Science::Medicine 58S Bioglass Cytotoxicity
Online Access:	https://hdl.handle.net/10356/172279
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-172279
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spelling	sg-ntu-dr.10356-1722792023-12-05T01:45:48Z Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study Chandran, Likha Marimuthu, Arumugam Abimanyu, Ravichandran Padmanabhan, Parasuraman Thirumavalavan, Munusamy Ballamurugan, Anbalagan M. Lee Kong Chian School of Medicine (LKCMedicine) Cognitive Neuroimaging Centre Science::Medicine 58S Bioglass Cytotoxicity The development of bone grafts and prosthetic implants for clinical need is still difficult due to the complexity of integrated physiological processes. The 58S glass ceramic is one of the most widely accepted biomaterial for preparing hard tissue damages due to its capability to react at molecular level. On the other hand, 58S glass ceramic are suffers some extent to expedite the new bone formation. The incorporation of rare earth elements into the bioactive glass ceramic matrix significantly improved the new bone formation. In addition, the cytotoxicity and biocompatibility properties of the obtained ceramic powder were investigated in vitro and in vivo for bone graft efficiency. The results showed that the rare earth elements in bioactive glass ceramic have the potential to repair damaged hard tissues. The authors gratefully acknowledge the financial support received from Indian Council of Medical research (ICMR), New Delhi, India, No. 35/14/2011-BMS, SRF-ICMR-No. 45/27/2019/NAN-BMS, RUSA 2.0- BEICH-No. BU/RUSA/BEICH/2019/52, and TNSCST-No. TNSCST/STP-PRG/AR/2018–2019. 2023-12-05T01:45:48Z 2023-12-05T01:45:48Z 2023 Journal Article Chandran, L., Marimuthu, A., Abimanyu, R., Padmanabhan, P., Thirumavalavan, M. & Ballamurugan, A. M. (2023). Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study. Materials Chemistry and Physics, 300, 127533-. https://dx.doi.org/10.1016/j.matchemphys.2023.127533 0254-0584 https://hdl.handle.net/10356/172279 10.1016/j.matchemphys.2023.127533 2-s2.0-85150029078 300 127533 en Materials Chemistry and Physics © 2023 Elsevier B.V. All rights reserved.
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Science::Medicine 58S Bioglass Cytotoxicity
spellingShingle	Science::Medicine 58S Bioglass Cytotoxicity Chandran, Likha Marimuthu, Arumugam Abimanyu, Ravichandran Padmanabhan, Parasuraman Thirumavalavan, Munusamy Ballamurugan, Anbalagan M. Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study
description	The development of bone grafts and prosthetic implants for clinical need is still difficult due to the complexity of integrated physiological processes. The 58S glass ceramic is one of the most widely accepted biomaterial for preparing hard tissue damages due to its capability to react at molecular level. On the other hand, 58S glass ceramic are suffers some extent to expedite the new bone formation. The incorporation of rare earth elements into the bioactive glass ceramic matrix significantly improved the new bone formation. In addition, the cytotoxicity and biocompatibility properties of the obtained ceramic powder were investigated in vitro and in vivo for bone graft efficiency. The results showed that the rare earth elements in bioactive glass ceramic have the potential to repair damaged hard tissues.
author2	Lee Kong Chian School of Medicine (LKCMedicine)
author_facet	Lee Kong Chian School of Medicine (LKCMedicine) Chandran, Likha Marimuthu, Arumugam Abimanyu, Ravichandran Padmanabhan, Parasuraman Thirumavalavan, Munusamy Ballamurugan, Anbalagan M.
format	Article
author	Chandran, Likha Marimuthu, Arumugam Abimanyu, Ravichandran Padmanabhan, Parasuraman Thirumavalavan, Munusamy Ballamurugan, Anbalagan M.
author_sort	Chandran, Likha
title	Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study
title_short	Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study
title_full	Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study
title_fullStr	Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study
title_full_unstemmed	Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study
title_sort	trivalent rare earth elements substitution in 58s bioactive glass matrix for bone repair applications - an in vitro and in vivo study
publishDate	2023
url	https://hdl.handle.net/10356/172279
_version_	1784855591207829504

Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study

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