Visualization of accessible cholesterol using a GRAM domain-based biosensor

• Main Authors: Koh, Dylan Hong Zheng, Naito, Tomoki, Na, Minyoung, Yeap, Yee Jie, Rozario, Pritisha, Zhong, Franklin, Lim, Kah-Leong, Saheki, Yasunori
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Medicine; Cholesterol; Lipid Transfer Protein
• Online Access: https://hdl.handle.net/10356/173010
• Institution: Nanyang Technological University

Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the distribution of cellular cholesterol is associated with numerous diseases, including neurodegenerative disorders. While regulated transport of a specific pool of cholesterol, known as "accessible choles...