Generation of four H1 hESC sublines carrying a hemizygous knock-out/mutant MECP2

by Zeng, Ruizhu, Sidik, Harwin, Robinson, Kim S, Zhong, Franklin L, Reversade, Bruno, Pouladi, Mahmoud A
Published 2019

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie
Published 2022

Visualization of accessible cholesterol using a GRAM domain-based biosensor

by Koh, Dylan Hong Zheng, Naito, Tomoki, Na, Minyoung, Yeap, Yee Jie, Rozario, Pritisha, Zhong, Franklin, Lim, Kah-Leong, Saheki, Yasunori
Published 2024

Structural basis of RIP2 activation and signaling

by Gong, Qin, Long, Ziqi, Zhong, Franklin L., Teo, Daniel Eng Thiam, Jin, Yibo, Yin, Zhan, Boo, Zhao Zhi, Zhang, Yaming, Zhang, Jiawen, Yang, Renliang, Bhushan, Shashi, Reversade, Bruno, Li, Zongli, Wu, Bin
Published 2019

Skin models for cutaneous melioidosis reveal Burkholderia infection dynamics at wound's edge with inflammasome activation, keratinocyte extrusion and epidermal detachment

by Ku, Joanne Wei Kay, Marsh, Supatra Tharinee, Nai, Mui Hoon, Robinson, Kim Samirah, Teo, Daniel Eng Thiam, Zhong, Franklin Lei, Brown, Katherine A., Lim, Thiam Chye, Lim, Chwee Teck, Gan, Yunn-Hwen
Published 2023

Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome

by Rozario, Pritisha, Pinilla, Miriam, Gorse, Leana, Vind, Anna Constance, Robinson, Kim S., Toh, Gee Ann, Muhammad Jasrie Firdaus, Martínez, José Francisco, Kerk, Swat Kim, Lin, Zhewang, Chambers, John Campbell, Bekker-Jensen, Simon, Meunier, Etienne, Zhong, Franklin
Published 2024

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

by Nadkarni, Rhea, Chu, Wern Cui, Lee, Cheryl Q. E., Mohamud, Yasir, Yap, Lynn, Toh, Gee Ann, Beh, Sheryl, Lim, Radiance, Fan, Michelle Yiyun, Zhang, Lyanne Yizhuo, Robinson, Kim, Tryggvason, Karl, Luo, Honglin, Zhong, Franklin, Ho, Lena
Published 2023

Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis

by Robinson, Kim Samirah, Toh, Gee Ann, Muhammad Jasrie Firdaus, Tham, Khek Chian, Rozario, Pritisha, Lim, Chrissie K., Toh, Ying Xiu, Lau, Zhi Heng, Binder, Sophie Charlotte, Mayer, Jacob, Bonnard, Carine, Schmidt, Florian I., Common, John E. A., Zhong, Franklin
Published 2023

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia.

by Robinson, Kim S, Teo, Daniel Eng Thiam, Tan, Kai Sen, Toh, Gee Ann, Ong, Hsiao Hui, Lim, Chrissie Kaishi, Lay, Kenneth, Au, Bijin Veonice, Lew, Tian Sheng, Chu, Justin Jang Hann, Chow, Vincent Tak Kwong, Wang, De Yun, Zhong, Franklin L, Reversade, Bruno
Published 2020

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

by Vind, Anna Constance, Wu, Zhenzhen, Muhammad Jasrie Firdaus, Snieckute, Goda, Toh, Gee Ann, Jessen, Malin, Martínez, José Francisco, Haahr, Peter, Andersen, Thomas Levin, Blasius, Melanie, Koh, Li Fang, Maartensson, Nina Loeth, Common, John E. A., Gyrd-Hansen, Mads, Zhong, Franklin, Bekker-Jensen, Simon
Published 2025

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

by Gong, Qin, Robinson, Kim, Xu, Chenrui, Huynh, Phuong Thao, Chong, Kelvin Han Chung, Tan, Eddie Yong Jun, Zhang, Jiawen, Boo, Zhao Zhi, Teo, Daniel Eng Thiam, Lay, Kenneth, Zhang, Yaming, Lim, John Soon Yew, Goh, Wah Ing, Wright, Graham, Zhong, Franklin L., Reversade, Bruno, Wu, Bin
Published 2022

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption

by Pinilla, Miriam, Mazars, Raoul, Vergé, Romain, Gorse, Leana, Paradis, Margaux, Suire, Bastien, Santoni, Karin, Robinson, Kim Samirah, Toh, Gee Ann, Prouvensier, Laure, Leon-Icaza, Stephen Adonai, Hessel, Audrey, Péricat, David, Murris, Marlène, Guet-Revillet, Hélène, Henras, Anthony, Buyck, Julien, Ravet, Emmanuel, Zhong, Franklin, Cougoule, Céline, Planès, Rémi, Meunier, Etienne
Published 2023

Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation

by Gorse, Léana, Plessis, Loïc, Wearne, Stephen, Paradis, Margaux, Pinilla, Miriam, Chua, Rae, Lim, Seong Soo, Pelluz, Elena, Toh, Gee Ann, Mazars, Raoul, Bomfim, Caio, Hervé, Fabienne, Lhaute, Korian, Réveillon, Damien, Suire, Bastien, Ravon-Katossky, Léa, Benoist, Thomas, Fromont, Léa, Péricat, David, Mertens, Kenneth Neil, Derrien, Amélie, Terre-Terrillon, Aouregan, Chomérat, Nicolas, Bilien, Gwenaël, Séchet, Véronique, Carpentier, Liliane, Fall, Mamadou, Sonko, Amidou, Hakim, Hadi, Sadio, Nfally, Bourdeaux, Jessie, Cougoule, Céline, Henras, Anthony K., Perez-Oliva, Ana Belen, Brehmer, Patrice, Roca, Francisco J., Zhong, Franklin, Common, John, Meunier, Etienne, Hess, Philipp
Published 2025