Generation of four H1 hESC sublines carrying a hemizygous knock-out/mutant MECP2

by Zeng, Ruizhu, Sidik, Harwin, Robinson, Kim S, Zhong, Franklin L, Reversade, Bruno, Pouladi, Mahmoud A
Published 2019

Understanding early molecular mechanisms of abnormal myelination in neurological conditions by characterising Ermin deficiency

by Oh, Sher Li, Ziaei, Amin, Tan, Liang Juin, Utami, Kagistia Hana, Pouladi, Mahmoud A., Langley, Sarah Raye
Published 2024

Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease

by Tano, Vincent, Utami, Kagistia Hana, Nur Amirah Binte Mohammad Yusof, Bégin, Jocelyn, Tan, Willy Wei Li, Pouladi, Mahmoud A., Langley, Sarah Raye
Published 2023

Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease

by Garcia-Miralles, Marta, Ooi, Jolene, Bardile, Costanza Ferrari, Tan, Liang Juin, George, Maya, Drum, Chester L, Lin, Rachel Yanping, Hayden, Michael R, Pouladi, Mahmoud A
Published 2022

Early white matter pathology in the fornix of the limbic system in Huntington disease

by Gabery, Sanaz, Kwa, Jing Eugene, Cheong, Rachel Y., Baldo, Barbara, Ferrari Bardile, C., Tan, Brendan, McLean, Catriona, Georgiou-Karistianis, Nellie, Poudel, Govinda R., Halliday, Glenda, Pouladi, Mahmoud A., Petersén, Å.
Published 2022

Urokinase plasminogen activator mediates changes in human astrocytes modeling fragile X syndrome

by Peteri, Ulla-Kaisa, Pitkonen, Juho, de Toma, Ilario, Nieminen, Otso, Utami, Kagistia Hana, Strandin, Tomas M., Corcoran, Padraic, Roybon, Laurent, Vaheri, Antti, Ethell, Iryna, Casarotto, Plinio, Pouladi, Mahmoud A., Castrén, M.L.
Published 2022

Unbiased profiling of isogenic huntington disease hPSC-derived CNS and peripheral cells reveals strong cell-type specificity of CAG length effects

by Ziaei, Amin, Zeng, Ruizhu, Low, Donovan, Aminkeng, Folefac, Sobota, Radoslaw M., Ginhoux, Florent, Petretto, Enrico, Pouladi, Mahmoud A., Langley, Sarah Raye, Ooi, Jolene, Xu, Xiaohong, Utami, Kagistia H., Sim, Bernice, Huang, Yihui, Harmston, Nathan P., Tay, Yi Lin
Published 2019

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells

by Augustine, George James, Pouladi, Mahmoud A., Xu, Xiaohong, Tay, Yilin, Sim, Bernice, Yoon, Su-In, Huang, Yihui, Ooi, Jolene, Utami, Kagistia Hana, Ziaei, Amin, Ng, Bryan, Radulescu, Carola, Low, Donovan, Ng, Alvin Yu Jin, Loh, Marie, Venkatesh, Byrappa, Ginhoux, Florent
Published 2017

Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease

by Radulescu, Carola I., Garcia-Miralles, Marta, Sidik, Harwin, Bardile, Costanza Ferrari, Nur Amirah Mohammad Yusof, Lee, Hae Ung, Ho, Eliza Xin Pei, Chu, Collins Wenhan, Layton, Emma, Low, Donovan, De Sessions, Paola Florez, Pettersson, Sven, Ginhoux, Florent, Pouladi, Mahmoud A.
Published 2021

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease

by Bardile, Costanza Ferrari, Garcia-Miralles, Marta, Caron, Nicholas S., Rayan, Nirmala Arul, Langley, Sarah Raye, Harmston, Nathan, Rondelli, Ana Maria, Teo, Roy Tang Yi, Waltl, Sabine, Anderson, Lisa M., Bae, Han-Gyu, Jung, Sangyong, Williams, Anna, Prabhakar, Shyam, Petretto, Enrico, Hayden, Michael R., Pouladi, Mahmoud A.
Published 2020

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

by Sorek, Matan, Oweis, Walaa, Nissim-Rafinia, Malka, Maman, Moria, Simon, Shahar, Hession, Cynthia C., Adiconis, Xian, Simmons, Sean K., Sanjana, Neville E., Shi, Xi, Lu, Congyi, Pan, Jen Q., Xu, Xiaohong, Pouladi, Mahmoud A., Ellerby, Lisa M., Zhang, Feng, Levin, Joshua Z., Meshorer, Eran
Published 2022

iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

by Park, Dong Shin, Kozaki, Tatsuya, Tiwari, Satish Kumar, Moreira, Marco, Khalilnezhad, Ahad, Torta, Federico, Olivie, Nicolas, Thiam, Chung Hwee, Liani, Oniko, Silvin, Aymeric, Phoo, Wint Wint, Gao, Liang, Triebl, Alexander, Tham, Wai Kin, Goncalves, Leticia, Kong, Wan Ting, Raman, Sethi, Zhang, Xiao Meng, Dunsmore, Garett, Dutertre, Charles Antoine, Lee, Salanne, Ong, Jia Min, Balachander, Akhila, Khalilnezhad, Shabnam, Lum, Josephine, Duan, Kaibo, Lim, Ze Ming, Tan, Leonard, Low, Ivy, Utami, Kagistia Hana, Yeo, Xin Yi, Di Tommaso, Sylvaine, Dupuy, Jean-William, Varga, Balazs, Karadottir, Ragnhildur Thora, Madathummal, Mufeeda Changaramvally, Bonne, Isabelle, Malleret, Benoit, Binte, Zainab Yasin, Da, Ngan Wei, Tan, Yingrou, Wong, Wei Jie, Zhang, Jinqiu, Chen, Jinmiao, Sobota, Radoslaw M, Howland, Shanshan W, Ng, Lai Guan, Saltel, Frederic, Castel, David, Grill, Jacques, Minard, Veronique, Albani, Salvatore, Chan, Jerry KY, Thion, Morgane Sonia, Jung, Sang Yong, Wenk, Markus R, Pouladi, Mahmoud A, Pasqualini, Claudia, Angeli, Veronique, Cexus, Olivier NF, Ginhoux, Florent
Published 2024