Polygenic risk scores for complex diseases: where are we now?

by Loh, Marie, Chambers, John Campbell
Published 2023

Investigating causal relationships between genetically determined increased risk of attention-deficit/hyperactivity disorder (ADHD) and atopic dermatitis (AD): A Mendelian randomiz...

by Ng, W, Loh, Marie, Yew, Yik Weng
Published 2023

Epigenetic disturbances in obesity and diabetes : epidemiological and functional insights

by Loh, Marie, Zhou, Li, Ng, Hong Kiat, Chambers, John Campbell
Published 2020

Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans

by Afaq, Saima, Kooner, Angad S., Loh, Marie, Kooner, Jaspal S., Chambers, John Campbell
Published 2019

Investigating causal relationships between Body Mass Index and risk of atopic dermatitis : a Mendelian randomization analysis

by Yew, Yik Weng, Loh, Marie, Thng, Steven Tien Guan, Chambers, John Campbell
Published 2021

Systematic evaluation of library preparation methods and sequencing platforms for high-throughput whole genome bisulfite sequencing

by Schuster, Stephan C., Beck, Stephan, Kim, Changhoon, Chambers, John Campbell, Loh, Marie, Zhou, Li, Ng, Hong Kiat, Drautz-Moses, Daniela I.
Published 2019

Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients

by Chan, Sze Ling, Chua, Angeline Poh Gek, Aminkeng, Folefac, Chee, Cynthia Bin Eng, Jin, Shengnan, Loh, Marie, Gan, Suay Hong, Wang, Yee Tang, Brunham, Liam R
Published 2022

Investigating causal relationships between obesity and skin barrier function in a multi-ethnic Asian general population cohort

by Yew, Yik Weng, Mina, Theresia, Ng, Hong Kiat, Lam, Benjamin Chih Chiang, Riboli, Elio, Lee, Eng Sing, Lee, Jimmy, Ngeow, Joanne, Elliott, Paul, Thng, Steven Tien Guan, Chambers, John Campbell, Loh, Marie
Published 2023

Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals

by Chen, Yuqing, Kassam, Irfahan, Lau, Suk Hiang, Kooner, Jaspal S., Wilson, Rory, Peters, Annette, Winkelmann, Juliane, Chambers, John C., Chow, Vincent T., Khor, Chiea Chuen, Van Dam, Rob M., Teo, Yik-Ying, Loh, Marie, Sim, Xueling
Published 2021

Smokeless and combustible tobacco use among 148,944 South Asian adults: a cross-sectional study of South Asia Biobank

by Xie, Wubin, Mridha, Malay Kanti, Gupta, Anaya, Kusuma, Dian, Butt, Awais Muhammad, Hasan, Mehedi, Brage, Soren, Loh, Marie, Khawaja, Khadija Irfan, Pradeepa, Rajendra, Jha, Vinita, Kasturiratne, Anuradhani, Katulanda, Prasad, Anjana, Ranjit Mohan, Chambers, John Campbell
Published 2024

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells

by Augustine, George James, Pouladi, Mahmoud A., Xu, Xiaohong, Tay, Yilin, Sim, Bernice, Yoon, Su-In, Huang, Yihui, Ooi, Jolene, Utami, Kagistia Hana, Ziaei, Amin, Ng, Bryan, Radulescu, Carola, Low, Donovan, Ng, Alvin Yu Jin, Loh, Marie, Venkatesh, Byrappa, Ginhoux, Florent
Published 2017

Adiposity impacts cognitive function in Asian populations: an epidemiological and Mendelian Randomization study

by Mina, Theresia, Yew, Yik Weng, Ng, Hong Kiat, Sadhu, Nilanjana, Wansaicheong, Gervais, Dalan, Rinkoo, Low, Dorrain Yan Wen, Lam, Benjamin Chih Chiang, Riboli, Elio, Lee, Eng Sing, Ngeow, Joanne, Elliott, Paul, Griva, Konstadina, Loh, Marie, Lee, Jimmy, Chambers, John
Published 2023

Investigation into the origins of an ancient BRCA1 founder mutation identified among Chinese families in Singapore

by Shaw, Tarryn, Chan, Sock Hoai, Teo, Jing Xian, Chong, Siao Ting, Li, Shao-Tzu, Courtney, Eliza, Ishak, Diana, Sankar, Haresh, Ang, Zoe Li Ting, Chiang, Jianbang, Loh, Marie, Zhou, Li, Lee, Soo Chin, Yeh, Hui-Yuan, Kolinjivadi, Arun Mouli, Lim, Weng Khong, Ngeow, Joanne
Published 2021

The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan

by Muilwijk, Mirthe, Loh, Marie, Mahmood, Sara, Palaniswamy, Saranya, Siddiqui, Samreen, Silva, Wnurinham, Frost, Gary S., Gage, Heather M., Jarvelin, Marjo-Riitta, Rannan-Eliya, Ravindra P., Ahmad, Sajjad, Jha, Sujeet, Kasturiratne, Anuradhani, Katulanda, Prasad, Khawaja, Khadija I., Kooner, Jaspal S., Wickremasinghe, Ananda R., van Valkengoed, Irene G. M., Chambers, John Campbell
Published 2023

Cohort profile : the diet and healthy aging (DaHA) study in Singapore

by Yu, Rongjun, Sun, Ye, Ye, Kaisy Xinhong, Feng, Qiushi, Lim, Su Lin, Mahendran, Rathi, Cheah, Irwin Kee-Mun, Foo, Roger Sik Yin, Chua, Ru Yuan, Gwee, Xinyi, Loh, Marie, Sarmugam, Rani, Khine, Wei Wei Thwe, Chao, Yin Xia, Larbi, Anis, Lee, Yuan Kun, Kumar, Alan Prem, Kennedy, Brian K., Kua, Ee-Heok, Feng, Lei
Published 2021

Cohort profile: the Diet and Healthy Aging (DaHA) study in Singapore

by Yu, Rongjun, Sun, Ye, Ye, Kaisy Xinhong, Feng, Qiushi, Lim, Su Lin, Mahendran, Rathi, Cheah, Irwin Kee-Mun, Foo, Roger Sik Yin, Chua, Ru Yuan, Gwee, Xinyi, Loh, Marie, Sarmugam, Rani, Khine, Wei Wei Thwe, Chao, Yin Xia, Larbi, Anis, Lee, Yuan Kun, Kumar, Alan Prem, Kennedy, Brian K, Kua, Ee Heok, Feng, Lei
Published 2022

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

by Kato, Norihiro, Loh, Marie, Takeuchi, Fumihiko, Verweij, Niek, Wang, Xu, Zhang, Weihua, Kelly, Tanika N., Saleheen, Danish, Lehne, Benjamin, Leach, Irene Mateo, Khor, Chiea-Chuen, Mok, Zuan Yu, Sapari, Nur Sabrina, Teh, Ai Ling, Cheng, Ching-Yu, Chong, Yap Seng, Koh, Woon-Puay, Lee, Jen-Mai Jeannette, Liao, Jiemin, Van Dam, Rob Martinus, Wong, Tien-Yin, Liu, Jianjun, Vithana, Eranga Nishanthie, Teo, Yik-Ying, Tai, E. Shyong
Published 2016

Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore

by Mina, Theresia, Xie, Wubin, Low, Dorrain Yanwen, Wang, Xiaoyan, Lam, Benjamin Chih Chiang, Sadhu, Nilanjana, Ng, Hong Kiat, Nur-Azizah Aziz, Tong, Terry Yoke Yin, Kerk, Swat Kim, Choo, Wee Lin, Low, Guo Liang, Halimah Ibrahim, Lim, Liming, Tai, E Shyong, Wansaicheong, Gervais, Dalan, Rinkoo, Yew, Yik Weng, Elliott, Paul, Riboli, Elio, Loh, Marie, Ngeow, Joanne, Lee, Eng Sing, Lee, Jimmy, Best, James, Chambers, John
Published 2024

Effects of choral singing versus health education on cognitive decline and aging : a randomized controlled trial

by Feng, Lei, Romero-Garcia, Rafael, Suckling, John, Tan, Jasmine, Larbi, Anis, Cheah, Irwin, Wong, Glenn, Tsakok, Maurine, Lanskey, Bernard, Lim, Darius, Li, Jialiang, Yang, Joanna, Goh, Benjamin, Teck, Tristan Gwee Chen, Ho, Allan, Wang, Xiu, Yu, Jin-Tai, Zhang, Can, Tan, Crystal, Chua, Michelle, Li, Junhua, Totman, John J., Wong, Caroline, Loh, Marie, Foo, Roger, Tan, Chay Hoon, Goh, Lee Gan, Mahendran, Rathi, Kennedy, Brian K., Kua, Ee-Heok
Published 2021

Effects of choral singing versus health education on cognitive decline and aging: a randomized controlled trial

by Feng, Lei, Romero-Garcia, Rafael, Suckling, John, Tan, Jasmine, Larbi, Anis, Cheah, Irwin, Wong, Glenn, Tsakok, Maurine, Lanskey, Bernard, Lim, Darius, Li, Jialiang, Yang, Joanna, Goh, Benjamin, Teck, Tristan Gwee Chen, Ho, Allan, Wang, Xiu, Yu, Jin-Tai, Zhang, Can, Tan, Crystal, Chua, Michelle, Li, Junhua, Totman, John J, Wong, Caroline, Loh, Marie, Foo, Roger, Tan, Chay Hoon, Goh, Lee Gan, Mahendran, Rathi, Kennedy, Brian K, Kua, Ee-Heok
Published 2022