A recurrent missense mutation in the EDAR gene causes severe autosomal recessive hypohidrotic ectodermal dysplasia in two consanguineous Kashmiri families

by Sadia, Foo, Jia Nee, Khor, Chiea Chuen, Jelani, Musharraf, Ali, Ghazanfar
Published 2021

Effects of bonding with parents and home culture on intercultural adaptations and the moderating role of genes

by PHUA, Desiree Y., MEANEY, Michael J, KHOR, Chiea Chuen, LAU, Ivy Yee-Man, HONG, Ying-Yi
Published 2017

A novel homozygous frameshift variant in XYLT2 causes spondyloocular syndrome in a consanguineous Pakistani family

by Kausar, Mehran, Chew, Elaine Guo Yan, Ullah, Hazrat, Anees, Mariam, Khor, Chiea Chuen, Foo, Jia Nee, Makitie, Outi, Siddiqi, Saima
Published 2019

Novel mutation G324C in WNT1 mapped in a large Pakistani family with severe recessively inherited Osteogenesis Imperfecta

by Kausar, Mehran, Saima Siddiqi, Muhammad Yaqoob, Sajid Mansoor, Makitie, Outi, Asif Mir, Khor, Chiea Chuen, Foo, Jia Nee, Anees, Mariam
Published 2019

Identification and in silico characterization of a novel p.P208PfsX1 mutation in V-ATPase a3 subunit associated with autosomal recessive osteopetrosis in a Pakistani family

by Ajmal, Muhammad, Mir, Asif, Wahid, Sughra, Khor, Chiea Chuen, Foo, Jia Nee, Siddiqi, Saima, Kauser, Mehran, Malik, Salman Akbar, Nasir, Muhammad
Published 2018

Case report: expanding the phenotype of ARHGEF17 mutations from increased intracranial aneurysm risk to a neurodevelopmental disease

by Ravindran, Ethiraj, Ullah, Noor, Mani, Shyamala, Chew, Elaine Guo Yan, Tandiono, Moses, Foo, Jia Nee, Khor, Chiea Chuen, Kaindl, Angela M., Siddiqi, Saima
Published 2023

Lens status influences the association between CFH polymorphisms and age-related macular degeneration: Findings from two population-based studies in Singapore

by Wong, Cheewai, Liao, Jiemin, Cheung, Chui Ming Gemmy, Khor, Chiea Chuen, Vithana, Eranga Nishanthie, Wang, Jiejin, Mitchell, Paul James, Aung Tin, Wong, Tienyin, Cheng Ching-Yu
Published 2015

Robust SNP-based prediction of rheumatoid arthritis through machine-learning-optimized polygenic risk score

by Lim, Ashley JW, Tyniana, C Tera, Lim, Lee Jin, Tan, Justina Wei Lynn, Koh, Ee Tzun, Chong, Samuel S, Khor, Chiea Chuen, Leong, Khai Pang G, Lee, Caroline G
Published 2023

Functional coding haplotypes and machine-learning feature elimination identifies predictors of Methotrexate Response in Rheumatoid Arthritis patients

by Lim, Ashley JW, Lim, Lee Jin, Ooi, Brandon NS, Koh, Ee Tzun, Tan, Justina Wei Lynn, Chong, Samuel S, Khor, Chiea Chuen, Tucker-Kellogg, Lisa, Leong, Khai Pang, Lee, Caroline G
Published 2022

Association analysis of PSAP variants in Parkinson's disease patients

by Chao, Yin Xia, Lee, Bernett, Ng, Ebonne Yulin, Lian, Michelle Mulan, Chew, Elaine Guo Yan, Tandiono, Moses, Li, Zheng, Khor, Chiea Chuen, Kumar, Prakash, Tan, Louis C. S., Foo, Jia Nee, Tan, Eng-King
Published 2021

Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals

by Chen, Yuqing, Kassam, Irfahan, Lau, Suk Hiang, Kooner, Jaspal S., Wilson, Rory, Peters, Annette, Winkelmann, Juliane, Chambers, John C., Chow, Vincent T., Khor, Chiea Chuen, Van Dam, Rob M., Teo, Yik-Ying, Loh, Marie, Sim, Xueling
Published 2021

Interaction effects between Paraoxonase 1 variants and cigarette smoking on risk of coronary heart disease in a Singaporean Chinese population

by Han, Yi, Dorajoo, Rajkumar S O, Ke, Tingjing, Ayala, Burger, Chang, Xuling, Khor, Chiea Chuen, van Dam, Rob M., Yuan, Jian Min, Koh, Woon Puay, Liu, Jianjun, Goh, Yam Thiam Daniel, Friedlander, Yechiel, Heng, Chew Kiat
Published 2016

The association of genetically determined serum glycine with cardiovascular risk in East Asians

by Chang, Xuling, Wang, Ling, Guan, Shou Ping, Kennedy, Brian K, Liu, Jianjun, Khor, Chiea-Chuen, Low, Adrian F, Chan, Mark Yan-Yee, Yuan, Jian-Min, Koh, Woon-Puay, Friedlander, Yechiel, Dorajoo, Rajkumar, Heng, Chew-Kiat
Published 2021

Machine learning using genetic and clinical data identifies a signature that robustly predicts methotrexate response in rheumatoid arthritis

by Lim, Lee Jin, Lim, Ashley JW, BRANDON OOI NICK SERN, Tan, Justina Wei Lynn, Koh, Ee Tzun, Group, Ttsh Rheumatoid Arthritis Study, Chong, Samuel S, Khor, Chiea Chuen, Tucker-Kellogg, Lisa, Lee, Caroline G, Leong, Khai Pang
Published 2022

The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

by Zhai, Weiwei, Choo, Su-Pin, Khor, Chiea Chuen, Lim, Tony Kiat-Hon, Zhang, Tong, Phang, Su-Ting, Tiang, Zenia, Guan, Peiyong, Ng, Ming-Hwee, Lim, Jia Qi, Yao, Fei, Li, Zheng, Ng, Poh Yong, Yan, Jie, Goh, Brian K., Chung, Alexander Yaw-Fui, Soon, Wendy Wei-Jia, Sung, Ken Wing-Kin, Foo, Roger Sik-Yin, Chow, Pierce Kah-Hoe
Published 2018

Pharmacogenomic Prediction of Bleomycin-Induced Pneumonitis in South East Asian Hodgkin Lymphoma Patients

by Lee, Joanne Shu Xian, Poon, Li Mei, Liu, Xin, Yuen, Yi Ching, Somasundaram, Nagavalli, Chin, Suk Teng, Teoh, Chia Meng, Yan, Benedict, Chan, Hian Li Esther, Chee, Yen-Lin, Tang, Tiffany, Farzana, Noorul, Aw, Caroline Hui Ting, Khor, Chiea Chuen, Ngeow, Joanne Yuen Yie, Ong, Choon Kiat, Tai, E Shyong, Chng, Wee Joo, Goh, Boon Cher, Lee, Soo Chin, Aminkeng, Folefac
Published 2022

Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population

by Chang, Xuling, Gurung, Resham L, Wang, Ling, Jin, Aizhen, Li, Zheng, Wang, Renwei, Beckman, Kenneth B, Adams-Haduch, Jennifer, Meah, Wee Yang, Sim, Kar Seng, Lim, Weng Khong, Davila, Sonia, Tan, Patrick, Teo, Jing Xian, Yeo, Khung Keong, Yiamunaa, M, Liu, Sylvia, Lim, Su Chi, Liu, Jianjun, van Dam, Rob M, Friedlander, Yechiel, Koh, Woon-Puay, Yuan, Jian-Min, Khor, Chiea Chuen, Heng, Chew-Kiat, Dorajoo, Rajkumar
Published 2021

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

by Kato, Norihiro, Loh, Marie, Takeuchi, Fumihiko, Verweij, Niek, Wang, Xu, Zhang, Weihua, Kelly, Tanika N., Saleheen, Danish, Lehne, Benjamin, Leach, Irene Mateo, Khor, Chiea-Chuen, Mok, Zuan Yu, Sapari, Nur Sabrina, Teh, Ai Ling, Cheng, Ching-Yu, Chong, Yap Seng, Koh, Woon-Puay, Lee, Jen-Mai Jeannette, Liao, Jiemin, Van Dam, Rob Martinus, Wong, Tien-Yin, Liu, Jianjun, Vithana, Eranga Nishanthie, Teo, Yik-Ying, Tai, E. Shyong
Published 2016

Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study

by Saw, Woei-Yuh, Tantoso, Erwin, Begum, Husna, Zhou, Lihan, Zou, Ruiyang, He, Cheng, Chan, Sze Ling, Tan, Linda Wei-Lin, Wong, Lai-Ping, Xu, Wenting, Kyin, Don Moong Nwe, Lim, Yenly, Li, Bowen, Pillai, Nisha Esakimuthu, Peterson, Trevor A, Bielawny, Tomasz, Meikle, Peter J, Mundra, Piyushkumar A, Lim, Wei-Yen, Luo, Ma, Chia, Kee-Seng, Ong, Rick Twee-Hee, Brunham, Liam R, Khor, Chiea-Chuen, Too, Heng Phon, Soong, Richie, Wenk, Markus R, Little, Peter, Teo, Yik-Ying
Published 2020

Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

by Wu, Degang, Dou, Jinzhuang, Chai, Xiaoran, Bellis, Claire, Wilm, Andreas, Shih, Chih Chuan, Soon, Wendy Wei Jia, Bertin, Nicolas, Lin, Clarabelle Bitong, Khor, Chiea Chuen, DeGiorgio, Michael, Cheng, Shanshan, Bao, Li, Karnani, Neerja, Hwang, William Ying Khee, Davila, Sonia, Tan, Patrick, Shabbir, Asim, Moh, Angela, Tan, Eng-King, Foo, Jia Nee, Goh, Liuh Ling, Leong, Khai Pang, Foo, Roger Sik Yin, Lam, Carolyn Su Ping, Richards, Arthur Mark, Cheng, Ching-Yu, Aung, Tin, Wong, Tien Yin, Ng, Huck Hui, Liu, Jianjun, Wang, Chaolong
Published 2021