Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia

by Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y, Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah Leong, Arumugam, Thiruma
Published 2022

Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia

by Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y., Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah-Leong, Arumugam, Thiruma V.
Published 2022

Effects of extended pharmacological disruption of zebrafish embryonic heart biomechanical environment on cardiac function, morphology, and gene expression

by Foo, Yoke Yin, Motakis, Efthymios, Tiang, Zenia, Shen, Shuhao, Lai, Jason Kuan Han, Chan, Wei Xuan, Wiputra, Hadi, Chen, Nanguang, Chen, Ching Kit, Winkler, Christoph, Foo, Roger Sik Yin, Yap, Choon Hwai
Published 2022

Cohort profile : the diet and healthy aging (DaHA) study in Singapore

by Yu, Rongjun, Sun, Ye, Ye, Kaisy Xinhong, Feng, Qiushi, Lim, Su Lin, Mahendran, Rathi, Cheah, Irwin Kee-Mun, Foo, Roger Sik Yin, Chua, Ru Yuan, Gwee, Xinyi, Loh, Marie, Sarmugam, Rani, Khine, Wei Wei Thwe, Chao, Yin Xia, Larbi, Anis, Lee, Yuan Kun, Kumar, Alan Prem, Kennedy, Brian K., Kua, Ee-Heok, Feng, Lei
Published 2021

Cohort profile: the Diet and Healthy Aging (DaHA) study in Singapore

by Yu, Rongjun, Sun, Ye, Ye, Kaisy Xinhong, Feng, Qiushi, Lim, Su Lin, Mahendran, Rathi, Cheah, Irwin Kee-Mun, Foo, Roger Sik Yin, Chua, Ru Yuan, Gwee, Xinyi, Loh, Marie, Sarmugam, Rani, Khine, Wei Wei Thwe, Chao, Yin Xia, Larbi, Anis, Lee, Yuan Kun, Kumar, Alan Prem, Kennedy, Brian K, Kua, Ee Heok, Feng, Lei
Published 2022

The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

by Zhai, Weiwei, Choo, Su-Pin, Khor, Chiea Chuen, Lim, Tony Kiat-Hon, Zhang, Tong, Phang, Su-Ting, Tiang, Zenia, Guan, Peiyong, Ng, Ming-Hwee, Lim, Jia Qi, Yao, Fei, Li, Zheng, Ng, Poh Yong, Yan, Jie, Goh, Brian K., Chung, Alexander Yaw-Fui, Soon, Wendy Wei-Jia, Sung, Ken Wing-Kin, Foo, Roger Sik-Yin, Chow, Pierce Kah-Hoe
Published 2018

Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease

by Tay, Kai Yi, Wu, Kan Xing, Chioh, Florence Wen Jing, Autio, Matias Ilmari, Pek, Nicole Min Qian, Narmada, Balakrishnan Chakrapani, Tan, Sock-Hwee, Low, Adrian Fatt-Hoe, Lian, Michelle Mulan, Chew, Elaine Guo Yan, Lau, Hwee Hui, Kao, Shih Ling, Teo, Adrian Kee Keong, Foo, Jia Nee, Foo, Roger Sik Yin, Heng, Chew Kiat, Chan, Mark Yan Yee, Cheung, Christine
Published 2023

Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer

by Sheng, Taotao, Ho, Shamaine Wei Ting, Ooi, Wen Fong, Xu, Chang, Xing, Manjie, Padmanabhan, Nisha, Huang, Kie Kyon, Ma, Lijia, Ray, Mohana, Guo, Yu Amanda, Sim, Ngak Leng, Anene-Nzelu, Chukwuemeka George, Chang, Mei Mei, Razavi-Mohseni, Milad, Beer, Michael A, Foo, Roger Sik Yin, Sundar, Raghav, Chan, Yiong Huak, Tan, Angie Lay Keng, Ong, Xuewen, Skanderup, Anders Jacobsen, White, Kevin P, Jha, Sudhakar, Tan, Patrick
Published 2021

Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy

by Chai, Ruth Jinfen, Werner, Hendrikje, Li, Peter Yiqing, Lee, Yin Loon, Khaing Thet Nyein, Solovei, Irina, Tuan Danh Anh Luu, Sharma, Bhavya, Navasankari, Raju, Maric, Martina, Sim, Lois Yu En, Loh, Ying Jie, Aliwarga, Edita, Cheong, Jason Wen Long, Chojnowski, Alexandre, Autio, Matias Ilmari, Haiyang, Yu, Boon Tan, Kenneth Kian, Keng, Choong Tat, Ng, Shi Ling, Chew, Wei Leong, Ferenczi, Michael, Burke, Brian, Foo, Roger Sik Yin, Stewart, Colin L.
Published 2022

Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain

by Ng, Gavin Yong-Quan, Sheng, Dominic Paul Lee Kok, Bae, Han-Gyu, Kang, Sung Wook, Fann, David Yang-Wei, Park, Jinsu, Kim, Joonki, Alli-Shaik, Asfa, Lee, Jeongmi, Kim, Eunae, Park, Sunyoung, Han, Jeung-Whan, Karamyan, Vardan, Okun, Eitan, Dheen, Thameem, Hande, Manoor Prakash, Vemuganti, Raghu, Mallilankaraman, Karthik, Lim, Lina HK, Kennedy, Brian K, Drummond, Grant R, Sobey, Christopher G, Gunaratne, Jayantha, Mattson, Mark P, Foo, Roger Sik-Yin, Jo, Dong-Gyu, Arumugam, Thiruma V
Published 2023

Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

by Wu, Degang, Dou, Jinzhuang, Chai, Xiaoran, Bellis, Claire, Wilm, Andreas, Shih, Chih Chuan, Soon, Wendy Wei Jia, Bertin, Nicolas, Lin, Clarabelle Bitong, Khor, Chiea Chuen, DeGiorgio, Michael, Cheng, Shanshan, Bao, Li, Karnani, Neerja, Hwang, William Ying Khee, Davila, Sonia, Tan, Patrick, Shabbir, Asim, Moh, Angela, Tan, Eng-King, Foo, Jia Nee, Goh, Liuh Ling, Leong, Khai Pang, Foo, Roger Sik Yin, Lam, Carolyn Su Ping, Richards, Arthur Mark, Cheng, Ching-Yu, Aung, Tin, Wong, Tien Yin, Ng, Huck Hui, Liu, Jianjun, Wang, Chaolong
Published 2021

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

by Cardoso, Alisson C, Lam, Nicholas T, Savla, Jainy J, Nakada, Yuji, Pereira, Ana Helena M, Elnwasany, Abdallah, Menendez-Montes, Ivan, Ensley, Emily L, Petric, Ursa Bezan, Sharma, Gaurav, Sherry, A Dean, Malloy, Craig R, Khemtong, Chalermchai, Kinter, Michael T, Tan, Wilson Lek Wen, Anene-Nzelu, Chukwuemeka G, Foo, Roger Sik-Yin, Ngoc, Uyen Nhi Nguyen, Li, Shujuan, Ahmed, Mahmoud Salama, Elhelaly, Waleed M, Abdisalaam, Salim, Asaithamby, Aroumougame, Xing, Chao, Kanchwala, Mohammed, Vale, Gonalo, Eckert, Kaitlyn M, Mitsche, Matthew A, McDonald, Jeffrey G, Hill, Joseph A, Huang, Linzhang, Shaul, Philip W, Szweda, Luke, Sadek, Hesham A
Published 2021

Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma

by Jeon, Ah-Jung, Teo, Yue-Yang, Sekar, Karthik, Chong, Shay Lee, Wu, Lingyan, Chew, Sin-Chi, Chen, Jianbin, Kendarsari, Raden Indah, Lai, Hannah, Ling, Wen Huan, Kaya, Neslihan Arife, Lim, Jia Qi, Ramasamy, Adaikalavan, Oguz, Gokce, Chung, Alexander Yaw-Fui, Chan, Chung Yip, Cheow, Peng-Chung, Kam, Juinn Huar, Madhavan, Krishnakumar, Kow, Alfred, Ganpathi, Iyer Shridhar, Lim, Tony Kiat Hon, Leow, Wei-Qiang, Loong, Shihleone, Loh, Tracy Jiezhen, Wan, Wei Keat, Soon, Gwyneth Shook Ting, Pang, Yin Huei, Yoong, Boon Koon, Ong, Diana Bee-Lan, Lim, Jasmine, de Villa, Vanessa H., dela Cruz, Rouchelle D., Chanwat, Rawisak, Thammasiri, Jidapa, Bonney, Glenn K., Goh, Brian K. P., Tucker-Kellogg, Greg, Foo, Roger Sik Yin, Chow, Pierce K. H.
Published 2023

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study

by Zhai, Weiwei, Lai, Hannah, Kaya, Neslihan Arife, Chen, Jianbin, Yang, Hechuan, Lu, Bingxin, Lim, Jia Qi, Ma, Siming, Chew, Sin Chi, Chua, Khi Pin, Alvarez, Jacob Josiah Santiago, Chen, Pauline Jieqi, Chang, Mei Mei, Wu, Lingyan, Goh, Brian K. P., Chung, Alexander Yaw-Fui, Chan, Chung Yip, Cheow, Peng Chung, Lee, Ser Yee, Kam, Juinn Huar, Kow, Alfred Wei-Chieh, Ganpathi, Iyer Shridhar, Chanwat, Rawisak, Thammasiri, Jidapa, Yoong, Boon Koon, Ong, Diana Bee-Lan, de Villa, Vanessa H., Dela Cruz, Rouchelle D., Loh, Tracy Jiezhen, Wan, Wei Keat, Zeng, Zeng, Skanderup, Anders Jacobsen, Pang, Yin Huei, Madhavan, Krishnakumar, Lim, Tony Kiat-Hon, Bonney, Glenn, Leow, Wei Qiang, Chew, Valerie, Dan, Yock Young, Tam, Wai Leong, Toh, Han Chong, Foo, Roger Sik-Yin, Chow, Pierce Kah-Hoe
Published 2023