Systematic evaluation of library preparation methods and sequencing platforms for high-throughput whole genome bisulfite sequencing

• المؤلفون الرئيسيون: Schuster, Stephan C., Beck, Stephan, Kim, Changhoon, Chambers, John Campbell, Loh, Marie, Zhou, Li, Ng, Hong Kiat, Drautz-Moses, Daniela I.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Science::Biological sciences; Genomics; Biotechnology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/85180; http://hdl.handle.net/10220/49792
• المؤسسة: Nanyang Technological University

Whole genome bisulfite sequencing (WGBS), with its ability to interrogate methylation status at single CpG site resolution epigenome-wide, is a powerful technique for use in molecular experiments. Here, we aim to advance strategies for accurate and efficient WGBS for application in future large-scal...