Visualization of accessible cholesterol using a GRAM domain-based biosensor

• المؤلفون الرئيسيون: Koh, Dylan Hong Zheng, Naito, Tomoki, Na, Minyoung, Yeap, Yee Jie, Rozario, Pritisha, Zhong, Franklin, Lim, Kah-Leong, Saheki, Yasunori
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Science::Medicine; Cholesterol; Lipid Transfer Protein
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/173010
• المؤسسة: Nanyang Technological University

Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the distribution of cellular cholesterol is associated with numerous diseases, including neurodegenerative disorders. While regulated transport of a specific pool of cholesterol, known as "accessible choles...