Targeting Cx43 to reduce the severity of pressure ulcer progression

• Main Authors: Kwek, Milton Sheng Yi, Thangaveloo, Moogaambikai, Madden, Leigh, Phillips, Anthony R. J., Becker, David Lawrence
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Medicine; Gap Junction; Necroptosis
• Online Access: https://hdl.handle.net/10356/173027
• Institution: Nanyang Technological University

In the skin, repeated incidents of ischemia followed by reperfusion can result in the breakdown of the skin and the formation of a pressure ulcer. Here we gently applied paired magnets to the backs of mice to cause ischemia for 1.5 h and then removed them to allow reperfusion. The sterile inflammato...