Targeting connexin 43 expression via scaffold mediated delivery of antisense oligodeoxynucleotide preserves neurons, enhances axonal extension, reduces astrocyte and microglial activation after spinal cord injury

Targeting connexin 43 expression via scaffold mediated delivery of antisense oligodeoxynucleotide preserves neurons, enhances axonal extension, reduces astrocyte and microglial activation after spinal cord injury

Injury to the central nervous system (CNS) provokes an inflammatory reaction and secondary damage that result in further tissue damage and destruction of neurons away from the injury site. Upon injury, expression of connexin 43 (Cx43), a gap junction protein, upregulates and is responsible for the s...

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Bibliographic Details
Main Authors: Chin, Jiah Shin, Milbreta, Ulla, Becker, David Lawrence, Chew, Sing Yian
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2023
Subjects:
Engineering::Bioengineering
Science::Medicine
Electrospinning
Gap Junction
Online Access:https://hdl.handle.net/10356/168840
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/168840

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