Targeting connexin 43 expression via scaffold mediated delivery of antisense oligodeoxynucleotide preserves neurons, enhances axonal extension, reduces astrocyte and microglial activation after spinal cord injury

• Main Authors: Chin, Jiah Shin, Milbreta, Ulla, Becker, David Lawrence, Chew, Sing Yian
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Science::Medicine; Electrospinning; Gap Junction
• Online Access: https://hdl.handle.net/10356/168840
• Institution: Nanyang Technological University

Injury to the central nervous system (CNS) provokes an inflammatory reaction and secondary damage that result in further tissue damage and destruction of neurons away from the injury site. Upon injury, expression of connexin 43 (Cx43), a gap junction protein, upregulates and is responsible for the s...