Targeting Cx43 to reduce the severity of pressure ulcer progression

• Main Authors: Kwek, Milton Sheng Yi, Thangaveloo, Moogaambikai, Madden, Leigh, Phillips, Anthony R. J., Becker, David Lawrence
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2024
• 主題: Science::Medicine; Gap Junction; Necroptosis
• 在線閱讀: https://hdl.handle.net/10356/173027
• 機構: Nanyang Technological University

In the skin, repeated incidents of ischemia followed by reperfusion can result in the breakdown of the skin and the formation of a pressure ulcer. Here we gently applied paired magnets to the backs of mice to cause ischemia for 1.5 h and then removed them to allow reperfusion. The sterile inflammato...