Chikungunya virus nonstructural protein 1 is a versatile RNA capping and decapping enzyme

• Main Authors: Law, Michelle Cheok Yien, Zhang, Kuo, Tan, Yaw Bia, Nguyen, Trinh Mai, Luo, Dahai
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Medicine; mRNA; Positive-Sense RNA Virus
• Online Access: https://hdl.handle.net/10356/173042
• Institution: Nanyang Technological University

Chikungunya virus (CHIKV) nonstructural protein 1 (nsP1) contains both the N7-guanine methyltransferase and guanylyltransferase activities and catalyzes the 5' end cap formation of viral RNAs. To further understand its catalytic activity and role in virus-host interaction, we demonstrate that p...