Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology

• Main Authors: Gaunt, Jessica Ruth, Zainolabidin, Norliyana, Yip, Alaric K. K., Tan, Jia Min, Low, Aloysius Y. T., Chen, Albert I., Ch'ng, Toh Hean
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Medicine; Alzheimer’s Disease; Microglia
• Online Access: https://hdl.handle.net/10356/173055
• Institution: Nanyang Technological University

Alzheimer's disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum compared to other brain regions, while the entorhinal cortex (EC) is one of the most vulnerable regions. Using a knock-in AD mouse model (App KI), we show that within the cerebellum, the...